淺沼 広子
ASANUMA Hiroko
| 所属/職位 | 臨床検査学科／教授 |
|---|---|
| 学位・資格等 | 医学博士（札幌医科大学） 法学士（法政大学） 臨床検査技師 認定病理検査技師 細胞検査士 国際細胞検査士 認定がんゲノム医療コーティネーター ISO16189内部品質監査員資格取得 |
| hrk-asanuma@jhu.ac.jp | |
| 主な担当科目 | 解剖学、病理学関係 |
| 所属学会 | 日本癌学会 日本病理学会 日本免疫学会 日本臨床細胞学会 日本臨床衛生検査技師会 （委員歴） 2003年4月-2021年3月 北海道細胞検査士会 学術委員 2004年4月-現在 札幌臨床検査技師会データ統一化プロジェクト委員 2004年4月-2018年3月 北海道臨床衛生検査技師会学術部門委員 2004年4月-現在 日本臨床細胞学会 理事 |
| 経歴 | 1983年 札幌医科大学附属病院検査部血液係 1985年 札幌医科大学附属病院病理部病理係 1987年 札幌医科大学附属病院検査部輸血係 1990年 札幌医科大学附属病院病理部病理係 2010年 札幌医科大学附属病院病理部病理係長 |
| 研究テーマと概要 | 【テーマ】 デジタル多重免疫染色法を用いた乳がん腫瘍微小環境の免疫病理学的解析 【概要】 乳がんにおける各サブタイプの免疫病理形質を分類し、免疫療法の感受性について解析する。 |
主な研究業績
| タイトル | 出典（雑誌名） | 巻号・ページ・発行年 | 単著・共著 |
|---|---|---|---|
| 【著書】 | |||
| JAMT技術教本シリーズ病理検査技術教本 | 丸善出版 | 第2版・2025年 | 共著 |
| 免疫染色 パーフェクトガイド | 医学書院 | 第1版第1刷2023年 | 共著 |
| 【総説】 | |||
| GIST病理診断標準化のための免疫染色 | 検査と技術（医学書院） | 2010; 38: 426-428 | 共著 |
| 迅速凍結標本作成法 | 検査と技術（医学書院） | 2003,31:1285-1291. | 共著 |
| 迅速診断の標本作成に最良な固定液の選定 | 臨床検査 （医学書院） | 2002,45:77-81 | 単著 |
| 非ホルマリン系固定液NoToXの使用経験 | 病理技術 | 1994,54:12-1 | 共著 |
| 抗血小板抗体の定量性測定法の試み-FCM法を用いて- | 現代医療（現代医療社） | 1990,22:125-130 | 単著 |
| β―グルクロニダーゼ染色 | 染色法のすべて（医歯薬出版） | 1984,84:145-147 | 共著 |
| 【原著論文】 | |||
| Immunohistological analysis of pancreatic carcinoma after vaccination withsurvivin 2B peptide : Analysis of an autopsy series. | Cancer Sci. | 110(8):2386-2395.2019 | 共著 |
| Randomized phase II trial of surviving 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarsinoma. | Cancer Sci. | 2378-2385.2019 | 共著 |
| Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6cases of clear cellsarcoma -like gastrointestineal tumor | Diagn Pathol | 13!1):73.20q8 | 共著 |
| コントロールの設定 | 検査と技術（医学書院） | Vol.46 No.9 1054-1061, 2018 | 共著 |
| Diagnostic utility of automated SureFISH (Dako Omnis) in the diagnosis of musculoskeletal translocation-related sarcomas. | Pathol Int | 67: 510-513, 201 | 共著 |
| NUTM2A-CIC fusion small round cell sarcoma: A genetically distinct variant of CIC-rearranged sarcoma. | Hum Pathol. | 65: 225-230, 2017 | 共著 |
| 乳腺・甲状腺穿刺吸引細胞診におけるLBCへの応用 | 北海道臨床細胞学会会 | 25: 10-14,2016 | 単著 |
| Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy. | Clin Cancer Res | 22: 3298-3309, 2016 | 共著 |
| Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy. | Oncotarget | 7: 11223-112237, 2016 | 共著 |
| Diagnostic use of fluorescence in situ hybridization in expert review in a phase 2 study of trabectedin monotherapy in patients with advanced, translocation-related sarcoma. | Diagn Pathol | 11: 37, 2016 | 共著 |
| Diagnostic utility of FOSB immunohistochemistry in pseudomyogenic hemangioendothelioma and its histological mimics. Diagn Pathol | Diagn Pathol | 11: 75, 2016 | 共著 |
| Phase I Clinical Study of Survivin-Derived Peptide Vaccine for Patients with Advanced Gastrointestinal Cancers. | J Cancer Clin Res | Vol.46 No.9 1054-1061, 2018 | 共著 |
| 成人の後腹膜に発生した多形型横紋筋肉腫の一例 | 北海道臨床細胞学会会報 | 24: 36-39,2015 | 共著 |
| Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. | Eur J Immunol | 45(7):2028-41. 2015 | 共著 |
| Smac13-Tat Fusion Peptide Induces Cell Death and Sensitizes HeLa Cells to Chemotherapeutic Drugs. | Int J Cancer Clin Res | 2:1,2015 | 共著 |
| Expression of hepatocyte growth factor in prostate cancer may indicate a biochemical recurrence after radical prostatectomy. | Anticancer Res | 35: 413-418, 2015 | 共著 |
| Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. | Lab Invest. | 94(12):1355-69. 2014 | 共著 |
| Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody. | J Biol Chem | 289: 22035-22047, 2014 | 共著 |
| A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma. | Am J Surg Pathol | 38: 1571-1576, 2014 | 共著 |
| 後腹膜神経内分泌腫瘍の一例 | 日臨細胞北海道会報 | 22: 38-41,2013 | 共著 |
| Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells. | PLoS One | 8: e69095, 2013 | 共著 |
| High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma. | PLoS One | 8: e84187, 2013 | 共著 |
| Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract. | Mod Pathol | 26: 117-124, 2013 | 共著 |
| Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma. | Virchows Arch | 462: 101-107, 2013 | 共著 |
| Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor. | Cancer Sci | 104: 431-436, 2013 | 共著 |
| ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. | PLoS One | 8: e65158, 2013 | 共著 |
| Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication. | Exp Cell Res | 319: 2617-2626, 2013 | 共著 |
| Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells. | Pathol Int | 63: 391-397, 2013 | 共著 |
| Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population. | PLoS One | 8: e68187, 2013 | 共著 |
| Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor. | Hum Pathol | 44: 1271-1277, 2013 | 共著 |
| Rapid on-site evaluation by endosonographer during endoscopic ultrasound-guided fine needle aspiration for pancreatic solid masses. | J Gastroenterol Hepatol | 28: 656-663, 2013 | 共著 |
| Validity and reproducibility of Ki-67 assessment in gastrointestinal stromal tumors and leiomyosarcomas. | Pathol Int | 63: 102-107, 2013 | 共著 |
| DNA methyltransferase 1 is essential for initiation of the colon cancers. | Exp Mol Pathol | 94: 322-329, 2013 | 共著 |
| Expression and function of FERMT genes in colon carcinoma cells. | Anticancer Res | 33: 167-173, 2013 | 共著 |
| 頭蓋底部に発生した脊索腫の２例 | 日臨細胞北海道会報 | 21: 60-65,2012 | 共著 |
| セルブロックによって悪性中皮腫との鑑別が可能となった肺腺癌の１例 | 日臨細胞北海道会報 | 21: 43-47,2012 | 共著 |
| High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis. | Pathol Int | 62: 684-689, 2012 | 共著 |
| HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells. | Cancer Res | 72: 2844-2854, 2012 | 共著 |
| Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues. | Pathol Int | 62: 303-308, 2012 | 共著 |
| TFE3関連融合遺伝子形成を伴った若年性腎癌の1例 | 日臨細胞北海道会報 | 20: 43-47,2011 | 共著 |
| SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity. | Lab Invest | 91: 1796-1804, 2011 | 共著 |
| Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrentoral cancer. | Cancer Sci | 102: 324-329, 2011 | 共著 |
| Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. | Am J Pathol | 178: 1805-1813, 2011 | 共著 |
| The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. | Exp Mol Pathol | 90: 55-60, 2011 | 共著 |
| 腺癌との鑑別が困難であったgoblet cell carcinoidの一例 | 日臨細胞北海道会報 | 2010; 19: 26-29 | 共著 |
| Use of tissue microarrays and immunohistochemistry to standardize the diagnosis of gastrointestinal stromal tumors. | Pathol Int | 60: 707-713, 2010 | 共著 |
| 北海道での細胞診プレパラートサーベイ「第15回」について | 日臨細胞北海道会報 | 18: 47-57,2009 | 共著 |
| 乳腺腺様嚢胞癌（adenoid cystic carcinoma）の1例 | 日臨細胞北海道会報 | 18: 43-46, 2009 | 共著 |
| Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. | J Immunother | 32: 474-485, 2009 | 共著 |
| Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4. | Cancer Sci | 100: 1485-1493, 2009. | 共著 |
| 乳癌の免疫逃避とそのメカニズムの解析 | 医学検査 | 57(4) : 779、2008 | 単著 |
| Identification of an immunogenic CTL epitope of HIFPH3 for immunotherapy of renal cell carcinoma. | Clin Cancer Res | 14: 6916-6923, 2008 | 共著 |
| Clinical and Immunological Evaluation of Anti-apoptosis Protein, Survivin-derived Peptide Vaccine in Phase I Clinical Study for Patients with Advanced or Recurrent Breast Cancer. | J. Translational Med. | 6: 24, 10 May, 2008 | 共著 |
| The enhanced expression of the matrix metalloproteinase 9 in nasal NK/T-cell lymphoma. | BMC Cancer | 8: 45, 2008 | 共著 |
| 肝膿瘍液中に異型細胞を認めた、後腹膜脱分化型脂肪肉腫の一例 | 日臨細胞北海道会報 | 16: 44-47, 2007 | 共著 |
| Down-regulation of HLA class I antigen is an independent prognostic factor for clear cell renal cell carcinoma. | J Urol | 177: 1269-1272, 2007 | 共著 |
| Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition. | J Urol | 178: 692-696, 2007 | 共著 |
| Expression of livin in renal cell carcinoma and detection of anti-livin autoantibody in patients. | Urology | 70: 38-42, 2007. | 共著 |
| Expression and antigenicity of surviving, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy. | Urology | 67: 955-959, 2006 | 共著 |
| Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus calmette-guerin immunotherapy for bladder cancer. | Clin Cancer Res | 12: 4641-4644, 2006 | 共著 |
| Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5. | Cancer Sci | 97: 1374-1380, 2006 | 共著 |
| Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue. | Histopathology | 48: 157-161, 2006 | 共著 |
| 副腎に発生した神経節芽腫（Ganglioneuroblastoma）の1例 | 日臨細胞北海道会報 | 14: 20-23, 2005 | 共著 |
| Survivin expression is regulated by coexpression of Human Epidermal Growth Factor Receptor 2 and Epidermal Growth Factor Receptor via Phosphatidylinositol 3-Kinase/AKT signaling pathway in breast cancer cells. | Cancer Res | 65: 11018-11025, 2005 | 共著 |
| A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis. | Cancer Res | 65: 8706-8714, 2005 | 共著 |
| Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. | Hum Pathol | 36: 234-241, 2005. | 共著 |
| A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis. | Cancer Res | 65: 8706-8714, 2005 | 共著 |
| Survivin expression is regulated by co-expression of HER2 and EGFR via PI3K-AKT signaling pathway in breast cancer cells. | Cancer Res | 65: 11018-11025, 2005 | 共著 |
| Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in Lung Cancer. | Clin Cancer Res | 11: 1000-1009, 2005 | 共著 |
| A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. | Clin Cancer Res | 11: 1474-1482, 2005 | 共著 |
| Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma. | J Transl Med | 3: 1, 2005 | 共著 |
| 乳腺invasive micropapillary carcinomaの1例 | 日本臨床細胞学会北海道支部会報 | 13: 27-30,2004 | 共著 |
| 耳下腺悪性筋上皮種の1例 | 日本臨床細胞学会北海道支部会報 | 13: 22-26,2004 | 共著 |
| 尿円柱の永久標本作成法 | 医学検査 | 53: 955-959.2004 | 共著 |
| 甲状腺の超音波像と病理組織診断の対比 | 医学検査 | 53: 267-271,2004 | 共著 |
| 尿細胞診に白血病細胞を認め腎転移が示唆された急性リンパ性白血病の1例 | 日本臨床細胞学会北海道支部会報 | 12: 39-42,2003 | 共著 |
| Localization and function in endoplasmic reticulum stress tolerance of ERdj3, a new member of Hsp40 family protein. Cell stress & chaperones. | Cell stress & chaperones | 64: 5442-5448,2004 | 共著 |
| Phase I Clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer. | Journal of Tanslational Medicine | 2: 19,2004 | 共著 |
| Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor. | Cancer Res | 64: 5442-5448, 2004 | 共著 |
| Expression of matrix metalloproteinase 9 is a prognostic factor in patients with non-Hodgkin lymphoma. | Cancer | 100: 356-365,2004 | 共著 |
| Localization and function in ER stress tolerance of ERdj3 molecule, a new member of HSP40 family protein. | Cell Stress & Chaperones | 9: 253-264, 2004 | 共著 |
| Detection of anti-livin antibody in gastrointestinal cancer patients. | Clinical Chemistry | 49: 1206-1208, 2003 | 共著 |
| 乳腺invasive micropapillary carcinoma症例の検討 | 日本臨床外科学会誌 | 64: 2369-2374,2003 | 共著 |
| 嚢胞形成を伴う腎オンコサイトーマの一例 | 日本臨床細胞学会北海道支部会報 | 11: 53-56,2002 | 共著 |
| High Throughputな迅速凍結標本の作製 | 医学検査 | 51: 1121-1126,2002 | 共著 |
| 髄液中に出現したT/NK cell Lymphomaの一例 | 日本臨床細胞学会北海道支部会報 | 10: 57-60,2001 | 共著 |
| 穿刺吸引細胞診で推定し得た同時性両側原発性乳癌の一例 | 日本臨床細胞学会北海道支部会報 | 9: 38-41,2000 | 共著 |
| 尿中に出現した腎細胞癌の一例 | 日本臨床細胞学会北海道支部会報 | 8: 1-44,1999 | 共著 |
| A monoclonal antibody, 3G12, reacts with a novel surface molecule Hal-1, with high expression in CD30-positive an aplastic large cell lymphomas. | Brit.J.Hematol | 106: 55-63,1999 | 共著 |
| 悪性中皮腫の免疫組織学的診断におけるカルレチニンの有用性について | 病理技術 | 58: 9-14,1998 | 共著 |
| 胞巣状軟部肉腫(alveolar soft part sarcoma) | 日本臨床細胞学会北海道支部会報 | 7: 59-63,1998 | 共著 |
| ヘリコバクターピロリに対する染色法(McMullen変法)を用いた簡便なレジオネラ菌の病理組織染色法 | 医学検査 | 46: 1496-1498,1998 | 共著 |
| Comparative cytology of stromal tumors of the gastrointestinal tract : A case report. | Tumor Reseach | 32: 41-48,1998 | 共著 |
| Cytology of malignant endocrine tumor of the pancreas : A case report. | Tumor Reseach | 32: 49-55,1998 | 共著 |
| 迅速捺印細胞診で診断し得た結膜悪性黒色腫の一例 | 日本臨床細胞学会北海道支部会報 | 5:55-59,1996 | 共著 |
| Helicobacter pylori(HP)の組織学的検査法 改良Genta法の実際と染色性 | 医学検査 | 44: 1552-1555,1995 | 共著 |
| Immunohistochemical detection of estrogen receptor in invasive human breast cancer: Correlation with heat shock protein, pS2 and oncogene products. | Oncology | 52: 371-375,1995 | 共著 |
| 二重染色 | EPOS文献集 | 54:9-10,1995 | 共著 |
| 三洋化成CA19-9試薬の臨床的評価 | 医学検査 | 42:973-978,1993 | 共著 |
| An Antiproliferative Monoclomnal Antibody,4F9,Reacts with aSubset of Human CD45 Molecules. | Tumor Research | 27:37-49,1993 | 共著 |
| Sysmex PAMIA-100における血中CA19-9測定の評価-第2報- | 臨床検査機器・試薬 | 14:307-313,1991 | 共著 |